G-quartet-forming property
WebJun 7, 2024 · In this study, we report G-quadruplex (G4)-forming DNA aptamers that upregulate the peroxidase activity in myoglobin specifically for luminol. Using in vitro … WebJun 1, 1991 · Classes of G-quartet structures The major guanine-quartet structures formed by DNA oligomers, examples of which are shown in Fig. 1, are: tetramolecular parallel quadriplexes (G4-DNA) [5,10.]; unimolecular antiparaUel quadriplexes (which we may term G4'-DNA) [6,7.,11",12.]; and, bimolecular anti- parallel quadriplexes (G'2-DNA) [7.,9o].
G-quartet-forming property
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WebJul 30, 2024 · Estimation of G-quartet-forming guanines in parallel-type G-quadruplexes by optical spectroscopy measurements of their single-nucleobase substitution sequences. †. Ryo Maruyama,a Kurumi Makino,a Toru Yoshitomi,a Hiroharu Yui, b Hitoshi Furusho c … WebAug 17, 2007 · G-quartets are structural motifs formed by guanine-rich sequences commonly occurring in the human genome. In this paper, we describe a capillary gel electrophoresis based method to validate G-quartet formation of in-house designed oligonucleotides and discuss the effect of monovalent cation concentration on the …
WebOct 10, 2015 · G-quadruplexes form in vitro in DNA or RNA sequences containing tracts of three to four guanine. ( A) The building blocks of G-quadruplexes are G-quartets that arise from the association of four … WebSep 9, 2016 · G-quadruplex structures are non-canonical four stranded secondary structures found in nucleic acid sequences that are rich in guanine residues. Four guanines can form a square planar tetrad in which each guanine serves as both a …
WebApr 21, 2024 · Characterization of G-quadruplex structures in the presence of monovalent ions (K +) and divalent ions (Ca 2+, Sr 2+, and Ba 2+ ). ( A) CD spectra of ions-induced … WebSep 11, 1998 · Intra molecular G-quartet formation was fast, as shown by a reversible denaturation profile, and even for temperature changes as fast as 3°C/min (15 times …
G-quadruplex forming sequences are prevalent in eukaryotic cells, especially in telomeres, 5` untranslated strands, and translocation hot spots. G-quadruplexes can inhibit normal cell function, and in healthy cells, are easily and readily unwound by helicase. However, in cancer cells that have mutated helicase these complexes cannot be unwound and leads to potential damage of the cell. This causes replication of damaged and cancerous cells. For therapeutic advances, stabiliz…
WebApr 30, 2002 · Several groups have demonstrated that G-rich oligonucleotides forming G-quartet structures display activity as potential drugs, such as potent HIV inhibitors. The delivery of G-quartet oligonucleotides to their intracellular targets is a key obstacle to overcome for their clinical success. ina horningerWebThe Uniform Partition of Heirs Property Act (UPHPA), a project that the American Bar Association’s Section of Real Property, Trust and Estate Law helped convince the Uniform Law Commission to undertake in 2007, seeks to address partition action abuses that have led many Americans to lose their tenancy-in-common property involuntarily in various ina horn bielefeldWebOct 7, 1998 · Intra molecular G-quartet formation was fast, as shown by a reversible denaturation profile, and even for temperature changes as fast as 3°C/min (15 times faster than in the experiment reported in Fig. 1 B), no … in a circle if a diameter bisects a chordWebJun 16, 2008 · The intramolecular formation of the G-quartet was demonstrated by 1 H NMR, NOESY, COSY, and HMQC and was definitively proved by X-ray diffraction in 2012. [191] Notwithstanding, no application... in a circle of radius 14 cm an arc subtendsWebOct 3, 2012 · In these tetramers, four guanine molecules form a square planar arrangement in which each guanine is hydrogen bonded to the two adjacent guanines (that is, a G-quartet ). Stacked G-quartets form a ... in a churn meaningWebparallel type T95-2T G-quadruplex, which was created based on PDB ID 2LK7 (color scheme: G-quartet-forming guanine (G), blue; thymine (T), green). S-4 Fig. S2 CD spectra of the T95-2T sequence and its single-nucleobase G-to-adenine (A) substitution sequences measured in DPBS (pH 7.4). The concentration of the ssDNA sample was 4 µM. in a circle of radius 14 cmWebNov 9, 2015 · The G-vacancy can be filled up by a guanine base from GTP or GMP to complete an intact G-quartet by Hoogsteen hydrogen bonding, resulting in significant G-quadruplex stabilization that can effectively alter DNA replication in vitro at physiological concentration of GTP and Mg 2+. in a circle which ratio is equivalent to π